It depends on where your going and how many people are going to the trip. But in my opinion I think about 3 times because you need to make stops when you need to use the restroom and when your hungry.
Sorry if I am not right :(
I hope I helped you have a great day :)
Answer:
PFFT this might help? sorry if not mate
Explanation:
Cell cycle checkpoint controls play a major role in preventing the development of cancer [see Sherr, 1994, for a more detailed discussion]. Major checkpoints occur at the G1 to S phase transition and at the G2 to M phase transitions. Cancer is a genetic disease that arises from defects in growth-promoting oncogenes and growth-suppressing tumor suppressor genes. The p53 tumor suppressor protein plays a role in both the G1/S phase and G2/M phase checkpoints. The mechanism for this activity at the G1/S phase checkpoint is well understood, but its mechanism of action at the G2/M phase checkpoint remains to be elucidated. The p53 protein is thought to prevent chromosomal replication specifically during the cell cycle if DNA damage is present. In addition, p53 can induce a type of programmed cell death, or apoptosis, under certain circumstances. The general goal of p53 appears to be the prevention of cell propagation if mutations are present. The p53 protein acts as a transcription factor by binding to certain specific genes and regulating their expression. One of these, WAF1 or Cip1, is activated by p53 and is an essential downstream mediator of p53-dependent G1/S phase checkpoint control. The function of p53 can be suppressed by another gene, MDM2, which is overexpressed in certain tumorigenic mouse cells and binds to p53 protein, thus inhibiting its transcriptional activation function. Other cellular proteins have been found to bind to p53, but the significance of the associations is not completely understood in all cases. The large number of human cancers in which the p53 gene is altered makes this gene a good candidate for cancer screening approaches.
I had to look for the missing options of this question and here is my answer:
Osteocyte is the term that describes the cells of the bone. These cells are formed in the mesenchyme. Once the bone matures, the processes then take place inside the Lacunae and the Canaliculi, respectively. Therefore, we can say that the structure that allows the provision of nutrients and removal of wastes from osteocytes would be the canaliculi.
<span>The gradual thickening of the uterine lining also called Endometrial Hyperplasia is often caused by having excess estrogen without enough progesterone to balance it. During menstruation, the estrogen causes the lining to thicken in preparation for pregnancy. When the progesterone is made during the second half of the cycle and the progesterone levels drop, the lining is shed. And if the ovulation didn’t occur, progesterone is not made and the lining is not shed properly, the lining will keep on building gradually that may lead to cancer in some women. </span>
