They knew that as time changed so that many aspects of society would change too. They needed to make a way so that the Constitution could still work effectively in modern times. The Constitution is still very effective today thanks to the amendments.
Samuel Adams was the leader of the Boston based Sons of Liberty and worked to lead protests against British taxation of the colonies after the 7-Years War.
More slaves would be required for the new cotton lands and it would be harmful to the people who were about to be enslaved because thousands were being sold for their labor.