Most cases of Cushing disease are sporadic, which means they occur in people with no history of the disorder in their family. Rarely, the condition has been reported to run in families; however, it does not have a clear pattern of inheritance.
The various syndromes that have Cushing disease as a feature can have different inheritance patterns. Most of these disorders are inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.
It would be Alcohol, any drug use,eating unhealthy, smoking,lack of working out, lol basically having intercourse at a young age without any protection, also unintentional injuries or violence.
P.s to prevent most of these all you need to know is right and wrong and if you know these thing can have consequences then don't do them also keep your legs closed , for one of them its important to work out every now and then
True,all forms of aerobic activity can promote cardio respiratory fitness.