Aliskiren was added to enalapril in individuals with chronic heart failure, however there was no improvement in the side effects in hypertension. In comparison to enalapril, noninferiority was not demonstrated for aliskiren.
Antihypertensive medications like enalapril have varying effects on blood pressure regulation, so for a synergistic effect, these medications are typically combined. Ninety percent of hypertension patients have an unknown underlying etiology. As a result, the primary function of antihypertensive medications such as enalapril is to change the body's regulatory systems (such as the renin-angiotensin-aldosterone system and baroreceptors) in order to maintain normal blood pressure. Enalapril at a dose of 5 or 10 mg twice daily for 2336 patients, aliskiren at a dose of 300 mg once daily for 2340 patients, or both therapies for 2340 patients of hypertension, to one of three groups (combination therapy). Heart failure hospitalization or death from cardiovascular causes made up the majority of the composite outcome in hypertension.
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Look up the questions 1 by 1 and then add the right words according to number of boxes
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<h2>Cholinergic and Adrenergic neurons</h2>
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The autonomic nervous system (ANS) is a dual innervations system which innervates internal organs of the body through the sympathetic and parasympathetic nervous system (PNS). Depending upon the neurotransmitter and receptor used, the ANS fibers are classified as cholinergic or adrenergic neurons.
The preganglionic neurons of the sympathetic and the preganglionic and postganglionic neurons of the parasympathetic nervous system release the neurotransmitter acetylcholine (ACH) and hence are called cholinergic neurons.
The postganglionic neurons of the sympathetic nervous system releases catecholamine like norepinephrine(NE) and hence called as adrenergic neurons.
The cholinergic neurons store ACH in the synaptic terminals. They are myelinated to aid in faster neurotransmission. The ACH neurotransmitter released from preganglionic neurons activates the two receptors – nicotinic ACH and muscarinic receptors on the postganglionic neurons
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The postganglionic neurons releasing NE binds to the adrenergic receptors – Alpha 1 and 2, Beta 1, 2, and 3.
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Trans fat also occurs naturally in food products from ruminant animals (e.g., milk, butter, cheese, meat products, etc.). Eating trans fat raises the level of LDL (“bad”) cholesterol in the blood.
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