Question

A patient who is recovering in hospital from a bilateral mastectomy has developed minor bleeding at one of her incision sites. During the process of clot formation, plasminogen will become part of a clot by which of the following means?A) By binding with fibrinB) By binding with plateletsC) By activating plasminD) By activating factor VII

Answer 1

Answer:

A. By binding with fibrin

Explanation:

When a blood clot forms, activation of fibrin occurs which is a network of fibrous mesh that traps cells in order to prevent blood loss. Formation of fibrin allows catalytically inactive plasminogen to bind to the fibrin network.

Plasminogen contains fibrin-binding domains of plasminogen called kringle domains which recognize and bind lysine residues of fibrin. This process allows tPA whic is serine protease to catalyze the conversion of plasminogen into plasmin which will start the breaking down process of the clot