I believe the answer you are looking for is It is destroyed, I hope this helps!
MAD (mitotic arrest deficient) are proteins related to spindle cell cycle checkpoint and it is important since they prevent the segregation of sister chromatids until all have bound to the spindle.
The cell cycle ensures the duplication of the genome and its distribution in daughter cells by passing through a coordinated and regulated sequence of events.
A series of checkpoints guarantee the orderly progression of the phases of cell division and the correct distribution of the duplicated genetic material in the daughter cells.
The checkpoints during mitosis are:
- At the end of stage G1 and before S.
- Before anaphase in mitosis.
- DNA damage checkpoints in G1, S or G2.
The checkpoint before anaphase in mitosis guarantees the separation of chromosomes, and operates by activating the Mad2 protein that prevents the degradation of segurin, until the conditions are appropriate.
That is, the Mad2 protein prevents the segregation of sister chromatids until they have all bound to the spindle.
Therefore, we can conclude that MAD (mitotic arrest deficient) are proteins related to spindle cell cycle checkpoint and it is important since they prevent the segregation of sister chromatids until all have bound to the spindle.
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Saline solutions have the same or close to the same amount of salt as our blood does, so we get the amount of salt needed for our bodies. During blood loss, you lose the salt you need, so they're basically adding it back in with the saline solution, making your electrolyte balance go back to normal level. It also gives us the right amount of water to keep us hydrated.
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