Answer:
1. P120 is degraded in the 26S proteasome
2. The 26S proteasome has a major role in protein degradation and is critical for protein homeostasis
3. Cell cycle and DNA replication are cellular processes regulated by the Ras and NFkB pathways
Explanation:
The proliferation-associated nucleolar protein (p120) is a protein known to be expressed during the interphase of the cell cycle, specifically in G1 and early S phase, where any problem with DNA replication trigger a checkpoint, i.e., a molecular cascade of signaling events that suspend DNA replication until the problem is resolved. In mammalian cells, the 26S proteasome is responsible for catalyzing protein degradation of about 80% (or even more) of their proteins. The 26S proteasome acts to degrade rapidly misfolded and regulatory proteins involved in the cell cycle, thereby having a major role in protein homeostasis and in the control of cellular processes. It is for that reason that inhibitors that block 26S proteasome function have shown to be useful as therapeutic agents in diseases associated with the failure of protein degradation mechanisms (e.g., multiple myeloma). The NF-κB are highly conserved transcription factors capable of regulating different cellular processes including, among others, cellular growth, inflammatory responses and apoptosis. Moreover, the MAPK/ERK pathway is able to transduce different signals received on the cell surface to the nucleus. The MAPK/ERK pathway is activated when a singling molecule binds to a cell receptor which triggers a signaling cascade that ends when a transcription factor induces the expression of target genes, ultimately producing a response in the cell (for example, the progression through the cell cycle).
Remind the parents to observe the child for :
1. excessive bleeding.
2. infection at the surgical incision site.
If any of these are observed, the child should get immediate medical attention.
Answer:
When the walleye pollock population decreased, there were more zooplankton available for the moon jellies to eat. Since the jellies had more energy storage molecules, they were able to reproduce more. This lead to more births than deaths in the moon jelly population, which caused the jelly population to increase.
Explanation:
here
During a myocardial infarction, proteins that are normally inside the cells leak into the plasma, due to loss of plasma membrane integrity.
<h3>Cardiac disorders and it's effects:</h3>
There are different types of cardiac or heart disorders that occurs due to different etiological origins.
Example of a cardiac disorder is the myocardial infarction.
Myocardial infarction is defined as the blockage of blood flow to the heart by the presence of blood clot.
This hinders the delivery of oxygen carried by the blood to tissue cells leading to apoptosis (which is a programmed cell death).
This will cause the plasma membrane of cells to lose its integrity leading to leaking of proteins into the plasma.
Learn more about myocardial infarction here:
brainly.com/question/1373449