Seminal vesicles
prostate gland
bulbourethral glands
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The heart is an organ (rather than a tissue) because it has an important (and complex) function. Tissues don't have nearly as many things in it as the heart does.
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The set of reactions that is the primary route of ATP production in the cells is called ETS REACTIONS. ETS stands for Electron Transport System. The reactions occur in the cristae of the mitochondria in the presence of cytochromes and coenzymes, which act as carrier molecules. They accept energized electrons and pass the electrons to the next molecules in the system. The overall reaction result in the production of ATP, which is the only form of energy that is usable by the cells.
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Several 2',3'-dideoxy-3'-thiapyrimidine nucleosides were studied for their ability to inhibit hepatitis B virus (HBV) DNA replication in a HBV-transfected cell line (2.2.15). 2',3'-Dideoxy-3'-thiacytidine (SddC) and 5-fluoro-2',3'-dideoxy-3'-thiacytidine(5-FSddC) were found to be the most potent anti-HBV compounds of those examined. Both compounds resulted in nearly complete cessation of viral DNA replication at 0.5 microM, as monitored by the absence of both intracellular episomal and secreted viral DNAs. The HBV-specific RNAs were not reduced at concentrations that completely blocked HBV DNA replication, suggesting that the inhibitory target is HBV DNA synthesis. The antiviral action of SddC and 5-FSddC was reversible. The concentration of SddC and 5-FSddC required to inhibit 50% of 4-day cell growth in culture was 37 microM and more than 200 microM, respectively. Unlike 2',3'-dideoxycytidine, these two compounds do not affect mitochondrial DNA synthesis in cells at concentrations lower than that required to inhibit cell growth. In view of the potent and selective antiviral activity, both SddC and 5-FSddC should be further evaluated for the treatment of human HBV infection.
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