1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
Eddi Din [679]
3 years ago
14

The pKa of an acid depends partly on its environment. Predict the effect of each of the following environmental changes on the p

Ka of a Glu side chain. Briefly explain why the pKa changes for each situation.
A) A lysine side chain is brought into proximity

B) The terminal carboxyl group of the protein is brought into proximity.

C) The glutamic acid side chain is shifted from the outside of the protein to a nonpolar site inside.
Biology
1 answer:
Galina-37 [17]3 years ago
3 0
The pKa represents the pH of the medium at which the zwitterionic amino acid assumes most stable ionic form due to structural stabilization. As the pKa is dependent upon the environmental factors of the solution around the amino acids, a change in their structure and localization can cause change in the pKa of the protein. Thus, the answers can be found as below:

Part A: Decrease (As the lysine is basic in nature, it will tend to stabilize the electrostatic interaction and weak interactions between the acidic amino acids and hydrogen bonds in the viscinity, thus lowering the pH and hence pKa of the protein)

Part B: Increase (As the carboxyl group is acidic in nature, removal of it will tend to increase the pKa since the basic amino acids will tend to accumulate more negative charge in their viscinity)

Part C: Increase (As glutamic acid is an acidic amino acid, its shift from outside to a non-polar site will prevents its ionization and hence the pKa will tend to shift from slightly acidic to slightly basic, hence increase)
You might be interested in
In arabidopsis, a mutation causing the b-class genes to be non-functional will result in the organ identity of the four whorls (
Contact [7]
In arabidopsis, a mutation causing the b-class genes to be non-functional will result in the organ identity of the four whorls to be; Sepal, sepal, Carpel, carpel. Arabidopsis is an angiosperm, a dicot from the mustard family Brassicaceae. It is widely used as a model organism in plant biology. It offers important advantages for basic research in genetics and molecular biology. 
7 0
3 years ago
According to Piaget's theory of cognitive development, which of the following is true of children in the concrete operational st
Anika [276]

Answer:

A. They center on the motives of wrongdoers as well as on the amount of damage done when assigning blame.

Explanation:

The Concrete Operational Stage, according to Piaget, refers to a stage that begins around age 7 and ends around the ages of 11 or 13.

During this stage, children are now capable of thinking in a more logical manner and their moral judgement has become subjective as <u>they now center on the motives of wrongdoers as well as on the amount of damage done when assigning blame</u>. For instance, they are able to judge another child according to the amount of damage she/he has done and whether it was done in purpose or accidentally.

They can also center on two dimensions of a problem at once and have thoughts that involve tangible objects instead of abstract ideas.

3 0
3 years ago
What makes the dna of a sunflower similar and different to the dna of a cat?
mariarad [96]
No estoy seguro que decir, pero sí es difícil
8 0
3 years ago
Which muscles act to propel food down the length of the pharynx to the esophagus?
Ksenya-84 [330]
Pharyngeal constrictor muscles (superior, middle and inferior)

The pharyngeal constrictor muscles are a group of muscles that form the lumen of the pharynx. After you swallow, an act that you have control, it starts a involuntary contraction by these muscles to propel  the bolus downwards.



4 0
3 years ago
Which change of state is shown in the model?
DiKsa [7]

Answer:

Where is the model?

4 0
3 years ago
Read 2 more answers
Other questions:
  • 01.03]Which of the following statements about science is true? Science is built on opinions and assumptions. Science is tested b
    12·2 answers
  • Please help me please
    8·1 answer
  • Sections of the digestive system type of break down what its being broken down to what is being absorbed
    5·1 answer
  • How does size affect whether something is living?
    7·1 answer
  • During the initial prenatal visit of a woman at 23 weeks' gestation, the nurse discovers that she has a history of pica. what is
    14·1 answer
  • Compare and contrast optical and radio telescope
    13·1 answer
  • Which stage of the listening process might include an alert posture, appropriate facial expressions, and direct eye contact?sele
    8·1 answer
  • The location of continents has no affect on their climate
    6·2 answers
  • Please help me
    8·1 answer
  • How much time does it take earth to travel from position b to position b?
    10·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!