Question

In sickle cell anemia, there is a replacement in the amino acid sequence of hemoglobin of glutamic acid by valine. what is the difference between glutamic acid and valine?

Answer 1

Valine is a hydrophobic amino acid used for biosynthesis of proteins.  It is essential in humans, meaning the body cannot synthesize it and it must be obtained from the diet.

Glutamic is a hydrophilic amino acid used by almost all living beings in the biosynthesis of proteins. It is non-essential in humans and the body can synthesize it.