Question

dentify and briefly discuss each mechanism ensuring against simultaneous fatty acid synthesis and oxidation in the same cell. Match the words in the left column to the appropriate blanks in the sentences on the right. ResetHelp A key intermediate in fatty acid synthesis, , carnitine acyltransferase I, thereby blocking the entry of fatty acyl units into the mitochondrion for oxidation. The substrates for fatty acid oxidation, , inhibit fatty acid synthesis by interfering with the polymerization of acetyl-CoA . Hormonal effects on adipocytes are opposed: promotes fatty acid by several mechanisms; promotes fat breakdown and fatty acid .

Answer 1

Answer:

Malonyl-CoA, a key intermediate in fatty acid synthesis, inhibits carnitine acyltransferase I, thereby blocking the entry of fatty acyl units into the mitochondrion for oxidation.

Fatty acyl-CoAs, the substrates for fatty acid oxidation, inhibit fatty acid synthesis by interfering with the polymerization of acetyl-CoA.

Hormonal effects on adipocytes are opposed; insulin promotes fatty acid synthesis by several mechanisms; while glucagon promotes fat breakdown and fatty acid oxidation