Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
The nurse administers cimetidine to a 75-year-old client diagnosed with a Gastric ulcer the nurse should monitor the client for the following adverse reactions Headache, Sleepiness, Confusion, Dizziness, Nausea which contribute for the change in Metal status.
- Cimetidine is a H
Receptor Antagonist. - Gastric partial cells contains receptors for Histamine.
- Histamine is released from the Enterochromaffin cells upon the stimulation from food intake or from Vagus nerve stimulation.
- Thus Histamine released from Enterochromaffin cells binds to H receptors on the parietal cells and increases the secretion of HCl.
- Cimetidine has totally opposite effect and decreases the secretion of HCl from the parietal cells.
- Not only on gastric cells H receptors are also present in CNS where they stimulate brain cells.
- The above point justifies the adverse effects of Cimetidine.
- Patients over the age of 50 or those who are severely ill may experience transient confusion while taking H
blockers, particularly cimetidine.
Hence from these points we can conclude that patients who are above 50 years and receiving Cimetidine medication for gastric ulcer should be monitored for the above mentioned adverse reactions.
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It is not unhealthy for us to take junk food as we usually, frequently and most of the times need them especially when we are very busy at work or busy to prepare normal dietary food
However the quality of the food we eat determines how well and healthy we would be.
<h3>What are nutrition?</h3>
Nutrition is simply means obtaining food substances
There are different types of nutrition
- Heterotrophic nutrition
- Autotrophic nutrition
Examples of junk foods include the following
- Biscuits
- Snacks
- Chocolates
- Sweets
So therefore, it is not unhealthy for us to take junk food as we usually, frequently and most of the times need them especially when we are very busy at work or busy to prepare normal dietary food but at the same time we should always find time to take mucj more healthy and nutritional food
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The pulse rate of the client most likely exhibits Tachycardia.
A nurse is someone who is educated to present care to individuals who are unwell or injured. Nurses work with doctors and other health care people to make patients nicely and to preserve their suit and healthy. Nurses also help with end-of-life needs and help another circle of relatives participants with grieving.
The number one role of a nurse is to be a caregiver for patients by way of handling bodily wishes, stopping infection, and treating health situations.
Nurses listen to and understand the concerns of their patients—which is important for evaluating conditions and growing treatment plans.
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Put the fluid in the bottle.
Put the bottle in the shot. Give it to someone.
