High concentrations of vasoconstrictor substances will increase the peripheral resistance.
Explanation:
Vasoconstriction substances cause blood vessels to narrow their lumen. The more narrow lumens, harder it is for the blood to go through that vessel. The reason for this is because the resistance increased, meaning that the friction between the blood and the vessels' walls is higher.
When we talk about peripheral resistance, it means the sum of all individual resistance of the body blood vessels (all arteries, all capillaries, all veins).
The easiest would be the circulatory system. BUT, i would suggest the nervous system! It is so interesting, with so many sub-systems existing within it. It’s on the more complex side tho
Explanation: The brain is basically the main nervous system, it travels down the spinal cord, and the sensory neurons are part of this system as well because nervous system in your limbs help you feel.