A rapid lateral flow immunoassay is presented that uses carboxyl-modified superparamagnetic nanoparticles as labels that can be quantified by highly sensitive multi-channel electronic readers. The approach is generic in that it is likely to be applicable to numerous small molecules. The method permits both single- and multiplex assays at a point-of-need without sample pretreatment. It is user-friendly and offers attractive characteristics demonstrated here for detection of morphine, fentanyl and methamphetamine in . The competitive immunoassay uses commercially available reagents that do not require special permissions. After migration of sample, the lateral flow test strips are subjected to an alternating magnetic field at two frequencies. The response from the nanolabels is readout at a combinatorial frequency from the entire volume of a porous immunochromatographic membrane by the magnetic particle quantification technique.
application to the determination of drugs of abuse.
Estimating the detection time of a drug in urine is complex because of many different influencing factors and the lack of experimental data. Detection times vary depending on dose and route of administration, metabolism and characteristics of the screening and confirmation assays. Using a cut-off value of 1000 ng/mL, urinary samples can be positive for amphetamine for up to 5 days after intake of the drug.
A temperature inversion is a thin layer of the atmosphere where the normal decrease in temperature with height switches to the temperature increasing with height. An inversion acts like a lid, keeping normal convective overturning of the atmosphere from penetrating through the inversion.
In rheumatoid Arthritis patients, NK cell levels were abnormally elevated, possibly due to high serum levels of IL-2.
Rheumatoid arthritis (RA), is an autoimmune disease that means our own immune system attacks self healthy cells in the body by mistake, causing inflammation (painful swelling),mainly attacks the joints.
The given study is to investigate the relationship between serum interleukin-2 (IL-2) levels and disease activity.
This study also showed the relationship between absolute numbers of peripheral lymphocyte subsets, autoantibodies, and associated cytokines in patients with rheumatoid arthritis (RA).
The results showed that the number and percentage of NK cells were positively correlated with serum IL-2 levels so, IL-2 can be a reason for elevated level of NK cells
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I think all of them are,polar bears have fur, penguins are suited for water and land, etc
In a deep wound, there might be a few layers of tissue that need to be rebuilt because they were lost. In this rebuilding process this pebbly texture can be seen and it indicates that granulation is taking place (that's the process). Granulation is when small blood vessels and capillaries start to develop vertically to the outside part of the wound, being supported by connective tissue, and surrounded by cells of many other types for different purposes, such as immunitary functions or specialised tissue functions. This tissue growing is characteristic of healing and it presents this granulated/pebbly texture to it.
