Phase 1 study is a trial of drug on humans, usually done in a small group of participants to evaluate the results of the experimental drug. It is tested to figure out intense the drug is, what are the side effects and how toxic it is. The dose is tested in different levels and on different people for best possible evaluation.
Subtract your age from 220 to get your maximum heart rate. Calculate your resting heart rate by counting how many times your heart beats per minute when you are at rest, such as first thing in the morning.