Phosphoryl-transfer potential is the ability of an organic molecule to transfer its terminal phosphoryl group to water which is an acceptor molecule. It is the “standard free energy of hydrolysis”.
Explanation:
This potential plays a key role during cellular energy transformation by energy coupling during ATP hydrolysis.
A compound with a high phosphoryl-transfer potential has the increased ability to couple the carbon oxidation with ATP synthesis and can accelerate cellular energy transformation.
A compound with a high phosphoryl-transfer potential can readily donate its terminal phosphate group; whereas, a compound with a low has a lesser ability to donate its phosphate group.
ATP molecules have a high phosphoryl transfer potential due to its structure, resonance stabilization, high entropy, electrostatic repulsion and stabilization by hydration. Compounds like creatine phosphate, phosphoenolpyruvate also have high phosphoryl-transfer potential.
The term "law" is a historical relic going back to Newtonian times, when after Newton's development of classical mechanics, it was thought that the workings of the universe were directly analagous to a perfectly constructed and perfectly predictable clockwork. That was turned on its head as a result of quantum mechanics, and modern scientists typically avoid use of the term "law" anymore because it is too dogmatic. Newton's "Laws" are still called that mainly for historical reasons now. What used to be called laws are now called theories.
The amoxicillin and the ampicillin are known to degrade the cell wall. both of these antibiotics have β- lactam in their structure. The structure of the ampicillin and the amoxicillin is similar having a single difference at the 4th position of benzene ring. The structure of the amoxicillin have an addition OH or hydroxyl group at the 4th position in the benzene ring.
As the structure of ampicillin and amoxicillin is similar, the bacteria having ampicillin resistance can also show amoxicillin resistance.
MODE OF ACTION OF AMOXICILLIN:
The amoxicillin binds with the pencillin binding proteins, present in the bacterial cell wall. The binding of the amoxicillin inhibits the enzyme transpepetidase, which is an important enzyme for the synthesis of the cell wall. it also inhibit murine hydrolases and inhibit the assembling of cell wall.
The amoxicillin effects the cell walls of the bacteria, as the animals cells do not have cell wall, they only have a cell membrane, the increase in the dose would not effect the animal cell.
