Yes. I have had one :). Called a canker sore
A continual "lub-dub, lub-dub" is a common way to characterize the sounds. The mitral valve and tricuspid valve closing is the source of the first "lub-dub." Following the first "lub-dub," the second "lub-dub" is made by the aortic and pulmonary valves shutting.
A blood backflow brought on by the heart's mitral valve failing to seal securely. When the mitral valve of the heart fails not close completely, blood can flow backward inside the heart, a condition known as mitral valve regurgitation. Breathing difficulties, weariness, dizziness, and an erratic, fluttering heartbeat are all symptoms. Treatment might not be necessary for everyone. Between the heart's two right chambers is where the tricuspid valve is located. There are three little flaps of tissue that make up the tricuspid valve (called cusps, or leaflets). These valve flaps open to let blood to flow from the right atrium, which is the upper chamber, to the right chamber, which is the lower chamber (right ventricle).
Learn more about mitral valve here:
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Answer:
Myelinated Axons; leak channels are insulated by myelin leading to less loss of current flow and better conduction velocity. Ion channels omly located at nodes of ranvier; thus signal has sultatory conduction along myelin sheaths and jumps and move much quicker
Demyelinating diseases; along locations where myelin sheaths once was current links occur and conduction slows, the signal cannot make it very far because it looses energy as it travels through the axon
Unmyelinated axon; Ion channels are sequentially placed all along axons; thus it takes longer to send signal down axon. the energy isn't leaked out, it still contains the same signal but it is simply slower. distance between voltage gated channels needs to be small enough so local current flow can depolarize the membrane.
N/B; Harder to generate action potential in demyelinating disease
axon diameter( bigger diameter= less resistance= faster current).
