Disruption of axonal transport would be a good target for his drug.
<h3>What is disruption of axonal transport?</h3>
- Axonal transport defects are among the early molecular events leading to neurodegeneration in mouse models of amyotrophic lateral sclerosis (ALS).
- Gene expression profiles indicate that dynactin-1 mRNA is downregulated in degenerating spinal motor neurons of autopsied patients with sporadic ALS.
- Disruption of axonal transport also underlies the pathogenesis of spinal muscular atrophy and hereditary spastic paraplegias.
- The neurotoxin β,β′-iminodipropionitrile (IDPN) selectively disrupts slow axonal transport without affecting fast anterograde or retrograde axonal transport.
- Impairment of slow axonal transport causes a proximal accumulation of neurofilaments.
- Because neurofilaments regulate axonal diameter, this accumulation leads to a marked swelling of the axon.
- Acrylamide causes decreased axonal transport, also causing proximal accumulations of neurofilaments and swelling.
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The cell is in METAPHASE PHASE OF MEIOSIS. At this phase, the pairs of homologous chromosomes moves to the cell equator. These pairs of homologous chromosomes will be separated in anaphase I. The number of chromosomes remains constant until the first cell division is completed, then the chromosomes will be divided into two daughter cells.
Human sperm and eggs contain 23 chromosomes. Human zygotes contain 46<span> chromosomes. The type of cell division that produces gametes with half the normal chromosome number is called meiosis. It is used to produce cells for repair and asexual reproduction.</span>
