The role of BiP in protein folding was briey described in this chapter. Answer the following questions

Biology

1 answer:

NISA [10]2 years ago

8 0

<h2>KDEL Sequence & Protein Unfolding</h2>

Explanation:

(a) The distinction between proteins sent out from and those held in the ER has all the earmarks of being represented by two unmistakable sorts of focusing on successions that explicitly mark proteins as either bound for transport to the Golgi or bound for maintenance in the ER. Numerous proteins are held in the ER lumen because of the nearness of the focusing on grouping Lys-Asp-Glu-Leu (KDEL, in the single-letter code) at their carboxy end. In the event that this succession is erased from a protein that is regularly held in the ER (e.g., BiP), the transformed protein is rather moved to the Golgi and emitted from the cell. On the other hand, the expansion of the KDEL arrangement to the carboxy end of proteins that are typically discharged makes them be held in the ER. The maintenance of some trans membrane proteins in the ER is comparatively directed by short C-terminal successions that contain two lysine deposits (KKXX sequences)

(b) Proteins are large molecules composed of folded chains of amino acids. Every protein has a unique shape and that shape determines the things it does. You could think of them as keys that fit into certain locks around the body Proteins do lots of different things around the body, including speeding up biological processes, recognizing antibodies, providing structure to certain body parts, transporting substances, regulating genes, and responding to signals inside and outside the body Proteins range in size from small ones, such as insulin - only 51 amino acids long, to extremely large ones, such as titin almost 27,000 amino acids long. No matter their size, they must be folded into a particular shape in order to function. Sometimes, though, things go wrong and cause the protein to unfold

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mart [117]

The answer is D, Oxygen

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2 years ago

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Leigh's disease is a mitochondrially inherited disease with symptoms that include seizures, fatigue, impaired reflexes, breathin

Ahat [919]

About the question:

You will find the pedigree in the attached files

Answer:

individual 4 → Affected woman → Black circle
individual 5 → Affected woman or man → Black circle or square
individual 7 → Healthy woman → Empty circle
individual 10 → Affected boy → Black Square

Explanation:

Mitochondrial inheritance is the transmission of a disease or a trait from the maternal line.

<em>Most of the DNI is in the nucleus, but there is also DNI in mitochondria. Sperm cells hardly transfer mitochondrial genes to the progeny</em>, so mitochondrial DNI is mostly inherited from the maternal side. If there exists any mutation in this mitochondrial DNI, the whole progeny of the mutated woman will be affected, as they will get the mother genotype carrying the mutation. On the contrary, if an affected man is carrying a mutation in mitochondrial DNI, non of their descendants will get the disease.

Before answering the question, let us remember the pedigree symbols.

Squares represent Males/Men
Circles represent Females/Women
Empty symbols represent healthy/non-affected individuals
Solid black symbols represent sick/affected individuals

In the exposed pedigree, we can see that the mother is affected by the disease (individual number 2), so all her children are also affected (individuals 4, 5, and 6) because the <em>disease is mitochondrially inherited</em>.

Individual 3 is a healthy man, so individual 4 must be an affected woman (Black circle). As she is the one affected, then all her children will also be affected. This couple <em>had one boy and two girls</em>. Individuals 8 and 9 are girls (circle), so individual 10 must be the affected boy (black square).

On the other hand, individual 6 is an affected man (black square), son of individuals 1 and 2. This man couples with a woman, and they have all healthy children. So this woman (individual 7) must be healthy. Even though the man is affected, all their children are not because their mother (7) is not. Remember that sperm cells do not transmit the mitochondrial genes to the progeny.

And finally, individual number 5 might be either a man or a woman. In any case, this person is also affected by Leigh's disease.