Bacitracin blocks the transport of nag and nam across the cytoplasmic membrane to the cell wall. Like other antimicrobials that block cell wall synthesis, this would result in weak cell walls and cell lysis. Antimicrobilas that act by inhibiting cell wall synthesis include beta-lactams, vancomycin and cycloserine and isoniazid and ethambutol among others. They prevent bacteria from increasing amount of peptidoglycan, they have no effect on existing peptodoglycan layer and therefore are effective only for growing cells.
Rabies virus nucleoprotein encapsidates the genomic and antigenomic RNA of RV to form the viral ribonucleoprotein complesx. Rabies virus is nonsegmented negative strand RNA virus within the Rhabdoviridae family.
It is zoonotic , aftal and progressive neurological infection caused by rabies virus of genus lyssavirus and family rhabdoviridae.Its genome is 12 kb in length and encodes 5 monocistronic mRNAs encoding the nucleocapsid protein, matrix, phosphoprotein, the trans-membrane, glycoprotein and viral RNA depent RNA polymerase.
Rabies virus vaccine vector tolerate large , multiple foreign genes , upt to 6.5 kb and live rabies virus vector with very low pathogenic potential can be constructed. It contains foreign glycoproteins such as hepatitis E2 or HIV .
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