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mash [69]
4 years ago
9

How does cell proliferation affect the symptoms and the course of Zollinger-Ellison syndrome?

Medicine
1 answer:
Jobisdone [24]4 years ago
4 0

Answer:

ascular endothelial cells are an established source of thrombospondin 1 (TSP1), a multifunctional extracellular matrix molecule. TSP1 appears to play an important role in modulating endothelial cell functions such as proliferation, migration, and capillary morphogenesis. In addition, TSP1 has recently been reported to potently inhibit angiogenesis both in vitro and in vivo. To better understand the mechanism underlying the antiangiogenic property of TSP1, endogenous TSP1 production was disrupted in bovine aortic endothelial cells (BAEC) by stable transfection with a vector expressing a TSP1 antisense RNA. Stable transfectants in which the antisense vector caused a decrease in TSP1 production were assayed for their ability to form capillary-like cords on gelled basement membrane matrix and for their responsiveness to the angiogenic/chemotactic mediator basic fibroblast growth factor. BAEC in which TSP1 production was disrupted exhibited a ten-fold increase over control BAEC in chemotactic activity to basic fibroblast growth factor and a twofold increase over control cells in the number of capillary-like cords that formed on gelled basement membrane matrix. Thus, the down-regulation of endogenous TSP1 appears to facilitate endothelial cell chemotaxis and capillary morphogenesis. These studies suggest that the modulation of TSP1 production is an important component of the angiogenic response, and support the idea that soluble TSP1 inhibits angiogenesis by interfering with endothelial cell chemotaxis and capillary formation.

Explanation:

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Answer:

B. Serotonin is a biogenic amine but not a catecholamine.

Explanation:

Catecholamines are the molecules which have an aminolaterral chain with a chatecol and  an amino group on their structure. Also, catecholamines are derived from an aminoacid called tyrosine. Instead, Serotonin is derived from an aminoacid called tryptophan and its structure does not contain the chemical compounds to be a catecholamine.

4 0
3 years ago
Describe a method of calculating the flow rate in the normal pump versus the pump with the narrowed vessels you described above.
charle [14.2K]

Answer:

Taking into account that:

The flow velocity u of a fluid is a vector field

u = u (x, t)

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q = || u ||

Now if the flow is continuous as it happens in the blood vessels then:

The flow of a fluid is said to be constant if it does not move over time, that is why the variant would be 0.

Explanation:

As for the pump with narrow vessels, there the area would be less, therefore the flow also and the flow velocity as well. Adding that the friction with the walls increases as it is narrower, thus generating an increase in pressure with the flow of the liquid.

So this is where we have to put emphasis on the biophysics branch that explains the following:

The Venturi effect is explained by the Bernoulli Principle and the principle of continuity of mass. If the flow rate of a fluid is constant but the section decreases, the speed necessarily increases after crossing this section. By the theorem of conservation of mechanical energy, if the kinetic energy increases, the energy determined by the value of pressure necessarily decreases.

Indeed, according to Bernoulli's principle:

P 1 + 21 ρv 12 + ρgh 1 = P 2 + 21 ρv 22 + ρgh 2

I don't know

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nataly862011 [7]

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