Question

A phenotypically normal prospective couple seeks genetic counseling because the man knows that he has a translocation of a portion of his chromosome 4, which has been exchanged with a portion of his chromosome 12. Although his translocation is balanced, he and his wife want to know the probability that his sperm will be abnormal. What is your prognosis regarding his sperm?

Answer 1

Answer:

Normal = 1/4, translocation 1/4, deletion and duplication 1/2.

Explanation:

Translocation may be defined as the process of movement of a part or a chromosome from one location to the another location of other chromosome. Here, the chromosome four is translocated and exchanged with the portion of chromosome 12.

The prognosis that can be inferred regarding the sperm is that the probability of the occurrence of normal chromosome is 1/4. This might be possible in the sperm that 1/4 chromosomes may undergo translocation. The chances of prognosis of deletion and duplication is 1/2.