Yes, it is true that Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia.
Focal malformations of cortical development, including focal cortical dysplasia (FCD) and hemimegalencephaly (HME), are important causes of intractable childhood epilepsy.
Using targeted and exome sequencing on DNA from resected brain samples and non-brain samples from 53 patients with FCD or HME, we identified pathogenic germline and mosaic mutations in multiple PI3K/AKT pathway genes in 9 patients, and a likely pathogenic variant in 1 additional patient.
Our data confirm the association of DEPDC5 with sporadic FCD but also implicate this gene for the first time in HME. Our findings suggest that modulation of the mammalian target of rapamycin pathway may hold promise for malformation-associated epilepsy.
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Answer:
Explanation:
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Scientist can communicate their findings by putting them on a journal and publish them
Explanation:
Monosaccharides are simple sugar molecules so they are individual sugar molecules and Polysaccharides are a combination of several sugar molecules
Answer:
b. a semi-permeable double layer of phospholipids that have hydrophilic heads and hydrophobic tails
Explanation:
B is correct as the cell membrane is selectively semi-permeable. It is selectively semi-permeable because this quality allows it to control what can and can't enter the cell, and how it does so.
The cell membrane also has a phospholipid bi-layer comprised of a double layer of phospholipids which have hydrophilic head and hydrophobic tails. This is because the heads are made of phosphate and are polar and are therefore attracted to water (hydrophilic), while the tails are made of lipids (i.e. fats, oils) which do not mix with water and are therefore hydrophobic.
The properties of each phospholipid is also why they form the double layer structure, the hydrophilic heads naturally face outwards into the water and protect the hydrophobic tails on the inside.
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