General anesthesia or general anesthetics can be defined as substances that triggers a loss of consciousness in individuals. These medications show their effect by activating inhibitory CNS and by inactivation of excitatory receptors of CNS.
They target both GABA (gamma-aminobutyric acid) and NMDA (N-methyl-D-aspartate) receptors of CNS. General anesthetics agonist effect with GABA receptors and antagonist effect with NMDA receptors, and induces state of unconsciousness.
