Extinction happens when there is a major climate change, then some species are unable to adapt to those changes, so they become extinct. Extinction basically occurs when species are unable to adapt quickly enough to the environment
Disruption of axonal transport would be a good target for his drug.
<h3>What is disruption of axonal transport?</h3>
- Axonal transport defects are among the early molecular events leading to neurodegeneration in mouse models of amyotrophic lateral sclerosis (ALS).
- Gene expression profiles indicate that dynactin-1 mRNA is downregulated in degenerating spinal motor neurons of autopsied patients with sporadic ALS.
- Disruption of axonal transport also underlies the pathogenesis of spinal muscular atrophy and hereditary spastic paraplegias.
- The neurotoxin β,β′-iminodipropionitrile (IDPN) selectively disrupts slow axonal transport without affecting fast anterograde or retrograde axonal transport.
- Impairment of slow axonal transport causes a proximal accumulation of neurofilaments.
- Because neurofilaments regulate axonal diameter, this accumulation leads to a marked swelling of the axon.
- Acrylamide causes decreased axonal transport, also causing proximal accumulations of neurofilaments and swelling.
To learn more about axonal transport,
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Autonomic nervous system:
-heart beats
-stomach digest
-produce bile
-feel a hot pain
-release adrenaline
-diaphragm relaxes
-colon contracts
-pancreas secretes
...............
somatic nervous system:
-make peace sign
-climb stairs
-curl tongue
-fingers curl
-point toes
-stretch arm
-fist clenches.
