Great Depression is the answer
<span> I think 1299 – May 29, 1453</span>
The northern borderlands of the Spanish colonies are now situated in the south of the United States. This place is rather dry and desertic compared with the centre of Mexico, what used to be the heart of the colonies. They didn't have the means to make it productive land and produce crops, and didn't have the workforce either. Indians living there were nomadic and offered great resistance to Spanish subjugation, the opposite from the tribes living in the centre of Mexico, sedentarian and already used to the dominance of an empire, the Aztec one.
The cotton gin lowered the price of coyton because so much was being produced due to the fact that it helped take the seeds out of the cotton much faster
Most likely the Native Americans that already lived there, as now settlers could now just move into their land and the Native Americans lost their land.