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Anuta_ua [19.1K]
3 years ago
7

The following pedigree tracks sickle cell disease through three generations of a family. Use the pedigree to answer the followin

g questions

Biology
1 answer:
kompoz [17]3 years ago
7 0

Answer:

See the answer with the explanation below.

Explanation:

Assuming the allele for sickle cell disease is represented by S and the alternate, non-sickle cell version is A; AA would be <em>homozygous normal</em>, AS would be <em>heterozygous normal</em>, and SS would be a <em>sickler</em>.

a. <em>The genotype of the father in the first generation would be </em><em>AS</em>.

The father is heterozygous, since the mother is affected and the couple produced an affected child. The cross can be illustrated thus:

AS (father)   x   SS (mother) = AS, AS, SS, SS

b. <em>The genotype of the daughter in the second generation would be </em><em>SS</em><em> </em>since she is phenotypically affected for the disease.

c. <em>The genotype of individual 3 in the second generation would be heterozygous, </em><em>AS</em>.

The cross between the the heterozygous normal father and the sickler mother can only produce one of heterozygous normal individuals or sickle cell diseased individuals. Hence, individual 3 has to be heterozygous since he appeared phenotypically normal in the pedigree.

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