I think it is in Tales of Suspense #39 that the cover dated March 1963. May 1968 Iron Man #1 received its own title.
Human monoclonal antibody (mAbs) are emerging in the field of cancer therapy and have become an increasing proportion of new drugs that are recently approved. Although there are some methods to obtain antigen-specific mAbs from human B cells, it is generally impossible to directly immunize human beings with antigens of interest. For example, for infectious agents, those approaches are largely restricted. To solve these obstacles, two main approaches have been developed; either by humanizing antigen-specific antibodies from small experimental animals (which is laborious due to the great genetic differences from humans) or rely on the in vitro selection of antigen-specific binders from human antibody repertoires. However, the human mAbs developed by these methods are usually with low affinity.
We are now coming up with a much better idea that is humanizing non-human primates mAbs instead of murine mAbs. Due to the close genetic relationship with humans, immunized NHPs have more potential to be isolated with high affinity antibody to human target than other experimental species, such as mouse, rat and rabbit. In addition, with appropriate method, NHP antibodies are much<span> easier to be humanized</span> without any loss of affinity compared to widely used murine antibodies.
Resource: http://www.creative-biolabs.com/High-Affi-TM-Human-Antibody-Discovery.html
1. Acceleration of impulse
2. Deceleration of impulse
Most of the downsides of recombinant DNA technology are ethical in nature. Some people feel that recombinant DNA technology goes against the laws of nature, or against their religious beliefs, due to how much control this technology gives humans over the most basic buildings blocks of life.
Other ethical concerns also exist. Some people worry that if companies can pay scientists to patent, buy and sell genetic material, then genetic material could become an expensive commodity. Such a system might lead to people having their genetic information stolen and used without permission. It may sound odd, but such cases have already happened. In 1951, a scientist used unique cells stolen from a woman named Henrietta Lacks to create an important cell line (the HeLa cell line) which is still used in medical research today. Her family did not know about her involuntary donation until after her death, and never received compensation, but others have profited from the use of HeLa cells.
Many people worry about the safety of modifying food and medicines using recombinant DNA technology. Although genetically modified foods seem safe in multiple studies, it is easy to see why such fears exist.
Hope this helps
Answer:
2
Explanation:
Glycolysis or EMP pathway is first stage of cellular respiration that occur in the cytoplasm of every living cell. It is a common process of both anaerobic and aerobic respiration. During glycolysis glucose, a 6 carbon sugar is converted into two molecules of pyruvate, a three carbon sugar. During this conversion 4 ATP molecules are produced. Two oxidise glucose to pyruvate, 2 ATP molecules are also required or used up. Thus, a net gain of 2 ATP molecules at the completion of glycolysis.
