Answer:
A DNA fragment with sticky end sequence TGGCA will bind with another DNA fragment with sticky end sequence ACCGT.
Explanation:
When a DNA strand is separated by the restriction endonuclease, it forms two separate single strands. These strands or cuts are known as sticky ends as they are detached from the complementary pairs.
These cuts of DNA are without complementary pairs and when they find suitable base pair, they get attached to it. These sticky ends are allowed to fix with the complementary base pairs during PCR/ polymerase chain reaction.
They are called sticky ends as they are ready to stick with the complementary base pairs of nucleotides.
Answer:
Aspirin works by inhibiting the production of prostaglandins. Aspirin inhibits the formation of prostaglandins by combining with the COX enzymes. Prostaglandins function as messenger molecules to monitor different physiological procedures in distinct regions of the body. One of the prime activities of prostaglandins is to stimulate inflammation and pain.
Prostaglandins are also the essential controller of platelet aggregation. By changing the COX enzymes inside the platelets, aspirin makes platelets to lose the stickiness, which is required to instigate clotting of blood.
There are two forms of cyclooxygenase, that is, COX-1 and COX-2. COX-1 generates prostaglandins and COX-2 mediates pain and swelling in response to tissue injury. Aspirin prevents both COX-1 and COX-2 functioning, while COX-2 is the therapeutic target of the drug.
However, it is the association of aspirin with COX-1 in the gastrointestinal tract, which results in the unwanted side effects of the drug. COX-1 is required to sustain a thick lining of the stomach. As aspirin inhibits the COX-1 enzyme, thus, the continuous use of the drug can result in the thinning of mucus, which safeguards the stomach from gastric juices.
In such cases, stomach bleeding, ulcers, and in certain situations perforation of the stomach can take place. Therefore, aspirin exhibits both bad and good effects.
Answer:
13 and 56 and 838 and 393 and 82 and 8
Explanation:
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