Answer:
The transport or circulatory system.
Disease: atherosclerosis.
How do I know: presence of a blood vessel (as indicated by the red blood cells within it) and the deposit of fat and/or cholesterol within the walls of the blood vessel.
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The correct answer in the missing blank is known as "separation".
The six degrees of separation is known as a theory in social networking wherein it states that a person can be connected anyone in the world, no matter how far, through a process of acquaintances, which possesses not more than five mediums.