<span>Nicotinic acetylcholine receptors (nAChR), are <span>ligand-gated ion channels and they can be a Na+, K+ and Ca2+ ion channel. Since nifedipine is a Ca2+ channel blocker (Ca2+ channel antagonist), it might inhibit the response of acetylcholine (if its receptor is Ca channel).</span></span>
As per Georg von Békésy's place theory, the position on the basilar film at which waves achieve their pinnacle relies upon the recurrence of a tone. High frequencies deliver waves that crest close to the shut end and are deciphered as shrill sound, while low-recurrence waves travel more remote, topping at the far end, and are translated as low-pitched.
They are both are types of explanations.
Temporary changes would be weather, since it can change at any givin time another example would be tides coming in because they vary by day, or wet sand becoming dry sand!