Answer and Explanation:
Ergotamine has been used for over 50 years and was the first specific drug to treat migraine attacks. Its therapeutic effect is due in part to its ability to contract the vessels. It is a vasoconstricting alkaloid used in migraine attacks, when treatment with non-steroidal anti-inflammatory drugs has no effect.
The mechanism of action of ergotamine is complex. The molecule has structural similarities to neurotransmitters such as seratonin, dopamine and adrenaline, and can therefore bind to various receptors and function as an inhibitor. Its use in the treatment of migraines is due to its vasoconstrictor effect of extracerebral intracranial blood vessels through their binding to the 5-HT1B receptor and inhibition of neurotransmitter binding.
Overuse of ergotamine may cause nausea, vomiting (to direct effects on the Central Nervous System in the vomiting centers) , malaise, headache, constriction of peripheral vessels and more severe effects such as ischemia of the extremities.
Ergotamine poisoning is called ergotism.
Ergotamine should not be used in patients with peripheral arterial or venous vascular insufficiency, ischemic heart disease, cerebrovascular disease, systemic infection and hypertension without effective control.
C because you suppose to get 8 but one more hour Is better
<span>-It all depends on <span>its size.
</span></span><span>-If it is a <span>man or a woman
</span></span><span>-depending on physical activity (important sedentary, middle<span>)
</span></span>
<span>For a low level of less than 30 minutes of activity a day, daily needs are of 2100 Kcalories. for moderate activity for 30 minutes of activity each day, are 2500-2 700 Kcalories and strong activity of more than 1 hour of activity per day, it is 3 000 3 500 Kcalories<span>.</span></span>
You could miss out on a lot of things like it could give you a shorter life, your could go to jail for owning certain drugs too. When having kids, when your older, drugs could affect the health of you and your child.
