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Answer:
No, CREs usually don't account for differences in gene expression levels.
Explanation:
<em>Cis</em>-regulatory elements (CREs) are non-coding DNA regions that regulate adjacent gene <em>transcription</em>. They usually do it by binding to transcription factors. They are in charge of influencing the rate of which transcription occurs, and less with how much a gene is expressed. On the other hand, trans-regulatory elements are DNA sequences that encode for upstream regulators that can modify or regulate <em>gene expression levels</em>.
Therefore, cis elements are not really in charge of expression levels, mostly transcription rates of single genes, rather. Trans elements are more involved in expression levels.
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