Answer:
African slaves were forcibly transported to the Americas
Rule by a single leader with unrestrained power.
Answer:
The states where, Missouri, Kentucky, Maryland, and Delaware. Later after Virginia spilt into two, the portion which was recognized as West Virginia choose to stay with the Union.
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The smallpox epidemic.
The millitary invasion was devastating but not to the extent of smallpox.
The Jesuits did not really devastate the New World.
Enslavement for sugar plantations mostly occurred with Africans.
Smallpox, brought in by the Columbian Exchange, had a widespread impact that killed a large portion of natives in the Americas.
So the Smallpox epidemic is the answer.