Answer:
Explanation:
The switch from glutamic acid to valine in position 6 of hemoglobin (HB) forms the basis of sickle cell anemia disease pathology.
Valine is hydrophobic and it's chain is shorter than glutamic acid. The lack of the carboxylic acid and shortness of valine will result in loss of the ionic interactions formed between the glutamic acid's carboxylic group and other amino acids. A hydrophobic cavity will form in the beta sheet of HB due to the short and hydrophobic structure of valine. For these reasons, the HB molecule will be less stable and insoluble in water. The insolubility is thought to be caused by fibril formation between the valine interacting with hydrophobic pocket residues of the adjacent HB molecule. This would in turn affect binding of oxygen to HB.
why must the bonds of these molecules be broken before anything else happens
Explanation:
yan po
Answer:
Gene mutation is most likely the cause of this difference from the rest of the population. Log in for more information.
Explanation:
CAN I GET BRAINLIEST
The answer is scientific theory. It amalgamates scientific law about objects and events that are widely accepted and tested. Scientific theory rationalizes phenomenon, that is not rigorously understood, through science. Examples of scientific theories today are the special relativity theory of Albert Einstein.
I had the same question and the answer was C OR A.
