Human monoclonal antibody (mAbs) are emerging in the field of cancer therapy and have become an increasing proportion of new drugs that are recently approved. Although there are some methods to obtain antigen-specific mAbs from human B cells, it is generally impossible to directly immunize human beings with antigens of interest. For example, for infectious agents, those approaches are largely restricted. To solve these obstacles, two main approaches have been developed; either by humanizing antigen-specific antibodies from small experimental animals (which is laborious due to the great genetic differences from humans) or rely on the in vitro selection of antigen-specific binders from human antibody repertoires. However, the human mAbs developed by these methods are usually with low affinity.
We are now coming up with a much better idea that is humanizing non-human primates mAbs instead of murine mAbs. Due to the close genetic relationship with humans, immunized NHPs have more potential to be isolated with high affinity antibody to human target than other experimental species, such as mouse, rat and rabbit. In addition, with appropriate method, NHP antibodies are much<span> easier to be humanized</span> without any loss of affinity compared to widely used murine antibodies.
Resource: http://www.creative-biolabs.com/High-Affi-TM-Human-Antibody-Discovery.html
Answer:
C,
Explanation:
The sand is just small rocks and pebbles broken down, we know that on a hot day rocks can heat up if left alone for long enough especially if they are dry.
I think it’s phenotype bc phenotypes is what the natural selection acts on bc it’s what interacts with an organisms environment and not the genotype.
Answer:
The xylem is located in the root, stem and the leaves of a plant.
The xylem contains dead cells arranged end-to-end forming continuous vessels. They have a hollow central space (lumen) through which water passes. They walls contain lignin.
The xylem carries water and minerals, up from the roots to the rest of the plant.
Answer:
1.chemical receptors
2. nerves carry signal to the brain
3. nerves carry signals to the muscle
4. the brain process these signals
5. the shark changes direction and swims towards pray
Explanation:
