Numerous antiepileptic medications, such phenytoin, have been designed to block voltage-gated sodium channels (VGSC) in neuronal membrane. In addition, multiple toxins and pharmacological modulators work by attaching to various biophysical states of the VGSC to cause their effects. Depending on how modulatory agents act, some VGSC states are stabilized or destabilized, altering the channel's biophysical properties. The first anticonvulsant to successfully treat epileptic disorders without causing undesirable side effects such as brain drowsiness was phenytoin.
Phenytoin has been indicated to block high-frequency neuronal activity potentials from the inner vestibule of the pore, as demonstrated by electrophysiological research and site-directed mutation.
Frequency and voltage both affect phenytoin binding.
There are theories that phenytoin interferes with the late sodium current that sustains depolarizations in epilepsy by blocking non-inactivated channels.
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Hand burning from stove-remove hand away from stove-somatosensory stimulus
Answer:
Hydrogen
Explanation:
hydrogen couldn't form until the universe had cooled enough to allow their nuclei to capture electrons, about 380,000 years after the Big Bang, Within about 3 minutes after the Big Bang, conditions cooled enough for these protons and neutrons to form hydrogen nuclei.
Invertebrates can be the least diverse
Answer:
Joan Walks 
miles farther than maria
Explanation:
Given:
Distance walked by Nicole = 1. 11/12 miles
Distance walked by Tasha= 2. 1/12 miles
Distance walked by Maria = 1. 7 /12 miles
Distance walked by Joan = 2. 2/12 miles
To find:
How much farther Joan walks to school than Maria = ?
Solution:
We can find the distance that Joan walk more than maria by subtraction
Joan distance - maria distance
here the distance are given in mixed fraction , so lets covert them into fraction and perform subtraction
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