Garrod hypothesized that "inborn errors of metabolism" such as alkaptonuria occur because...genes dictate the production of specific enzymes, and affected individuals have genetic defects that cause them to lack certain enzymes.
Explanation:
Archibald Garrod researched on alkaptonuria and proposed the ‘one gene-one enzyme’ hypothesis. This led to the finding that alkaptonuria is caused due to an inherited or “inborn error of metabolism”.
This hypothesis stated that each gene codes and responsible for a single specific enzyme which facilitates a particular step in the metabolic processes.
According to Garrod, a mutation of a particular gene leads to specific error or defect leading to a lack of a particular enzyme that takes part in the biochemical metabolic pathways. This disrupts the metabolic pathway at the specific enzymatic action point.
In alkaptonuria, it was found that the defective phenotype of dark urine is due to the inborn error happening during the waste elimination process.
Answer:
- Mediation
- Arbitration
- Litigation
Explanation:
Dispute resolution process depends on negotiation. People involved in dispute should aim to reach an agreement through dispute resolution processes.
Following things are important in resolving an dispute which includes:
- Keep yourself calm
- Think of creative solutions
- seek assistance and talk to other party
Mediation:
Mediation is an interactive process where a neutral third party assists disputing parties in resolving conflicts.
Arbitration:
Arbitration is a form of alternative dispute resolution, in a way to resolve a dispute outside the court. The dispute will be decided by two or more persons.
Litigation:
A litigation is a process of proceeding by a party or parties against another in the civil court of law.
Uterosacral ligament suspension and sacrospinous fixation.
