1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
jekas [21]
4 years ago
5

Individuals without AFS have a glutamic acid at position 487 on the ALDH2 protein, whereas individuals with AFS have a lysine at

this position. Using what you determined in 1.2, provide a plausible chemical explanation justifying why the properties of the enzyme could be so drastically altered by this single amino acid substitution. Keep in mind that the enzyme has two substrates, one of which is acetaldehyde and the other is NADH or NAD+
Biology
1 answer:
azamat4 years ago
8 0

Answer:

Aldehyde Dehydrogenase 2 (ALDH2) is an enzyme required to eliminate toxins such as acetaldehyde and alcohol, thereby mutations in this protein may be associated with the Alcohol flush syndrome (AFS)

Explanation:

ALDH2 is a protein required for ATP generation by catalyzing the oxidation of aldehydes to carboxylic acids (i.e., oxidation of NADH to NAD+). Mutations in the ALDH2 gene have been associated with the inactive form of this enzyme, and this specific mutation at position 487 alters its enzymatic activity associated with the metabolism of acetaldehyde and alcohol. This amino acid substitution may lead to the active site-directed inactivation of the enzyme.

You might be interested in
I don't understanding this as much
algol13
I am thinking D. But I am not sure that it is the answer.
7 0
4 years ago
It is important to understand the differences between chemical and physical changes which process is an example of a physical ch
Bas_tet [7]
A physical change is basically a body change so like if a crayon is solid then sits in the sun for a long time it melts away that’s a physical change because it changes its physical appearance
7 0
3 years ago
Read 2 more answers
Is ACHOO syndrome an inherited disorder?
Zigmanuir [339]
Yes, if 1 parent has it then the child has a 50% chance of having it
4 0
3 years ago
66.) Match the six kingdoms with the characteristics that describe them.
Vikentia [17]

Answer:

I'm sure you'll find your answer some time soon

3 0
3 years ago
Read 2 more answers
NEED HELP ASAP due today
Ann [662]

Answer:

A river forms from water moving from a higher elevation to a lower elevation, all due to gravity. Flowing water finds its way down a slope initially as small creeks. As small creeks flow downhill they shape larger streams and rivers. Rivers eventually end up flowing into the oceans with much more speed than was originally there.

Hope it helps and I did it correctly and used that words I needed to.

7 0
3 years ago
Other questions:
  • Examine the following diagram. Place the labeled layers in order from youngest to oldest.
    10·2 answers
  • Match the atomic particles with their electrical charges.
    12·1 answer
  • How are changes in populations related to the availability of an ecosystem's resources?
    5·1 answer
  • What is the complementary base sequence of the DNA strand if the template strand reads TTGCACG? A. CCTATGC B. TTGCGGC C. AACGTGC
    15·1 answer
  • In the genetic disease cystic fibrosis, ducts in several organs become blocked by an excessive production of thick mucus. Althou
    10·1 answer
  • The carrier molecules of the electron transport system are located in the
    13·2 answers
  • A bird is flying in the air at a 4 m/s. If the mass of the bird is 7kg what is it’s kinetic energy
    8·2 answers
  • I put the question in the picture
    10·2 answers
  • Help me, please. It's my first time asking a biology question.
    6·1 answer
  • Write a one-paragraph reflection to discuss the learning connections you made using the letter prompts, and how they relate to t
    11·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!