What is your interpretation of a suffix?1 a group of letters that have a specific meaning and can appear at the beginning of many different words is called a suffix. 2 a suffix is like a prefix, only it comes at the end of the word. 3 a group of letters that have a specific meaning and can appear in the middle of different words is called a suffix. 4 a suffix is like a prefix, only it comes at the beginning of a word.