Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
If he is trying to consume 30% of his calories from fat, he should consume 33 grams of fat.
<h3>How much fat should I consume per day?</h3>
The WHO recommendation is to consume up to 30% fat of the total calories ingested per day. That's considering a diet of 2000 kcal/day.
With this information, we can conclude that if he is trying to consume 30% of his calories from fat, he should consume 33 grams of fat.
Learn more about calories from fat per day in brainly.com/question/1085929
#SPJ1
Answer: Option 1) Medicaid
Explanation:
Through the value based purchasng initiative enacted by Affordable Care Act, in US Healthcare, decided to expand the services of medicaid.
Medicaid provide government sponsored insurance program to the individuals with low income. Medicaid expansion involves that it wil provide long term health care services and pay all the health benefits for more than 70 million people.
Medicaid expansion become efficient health care program as it covers populations with low income, including young children, pregnant women and physically or mentally disable adults. Peopleadded in this program on different eligibility varies widely among states to meet all the states with minimum federal need.
Hence, the correct option is 1) Medicaid.
Answer:
Medicare Part D drug plans may have different benefit structures, but on average, they must all be at least as good as the standard model established by the government.
Explanation:
