Exhaustion would be a key answer to this but they're others if needed.
I mean, not all do? But in Japan, looking nice is a (really) common thing. I assume they just take really good care of their hair though. And the black, could be natural or dyed.
Cardiovascular system goes with Atherosclerosis
Digestive system goes with Cirrhosis
Endocrine system goes with Addison's disease
Immune system goes with Mononucleosis
Bacterial vaginosis it is true answer
I am about 100 percent sure its D