Question

Quizlet: Aspirin is known to cause stomach ulcers when taken too often owing to its inhibition of COX-1, which is constitutively expressed, and the prostaglandin product signals for localized cellular housekeeping, not pain and swelling. In contrast, COX-2 is induced (produced) when, for example, you get cut or punched in the face; then its prostaglandin product signals pain and swelling. Identify the shape-based structural features and electostatics-based structural features that would lead to a selective COX-2 inhibitor to avoid the side effects of aspirin. Don't forget to consider the intracellular location of these peripheral membrane-bound enzymes.

Answer 1

Solution :

Aspirin is used to reduce fever and also relief the mild pain from the body by the conditions including toothache, headaches, muscle pains, and minor body pains.

It is a nonsteroidal anti-inflammatory drug and also a blood thinners.

Shape-based structural features

--  The inhibitor should be L or V shaped to selectively bind to COX -2.

Electrostatics based structural features

The inhibitor should include a carboxylic acid to target Arg 120

Incompatible structural feature