Warfarin acts by inhibiting the activity of the VKORC1 protein, which helps to produce functional clotting factors. There is a v
ariant in the VKORC1 gene that lowers the dose of warfarin required for treatment, and individuals with this variant have increased risk of bleeding when they are treated with warfarin. This variant is found 1639 base pairs upstream of the translational start site. This variant likely:______. a. decreases the activity of the VKORC1 protein.b. increases the activity of the VKORC1 protein.c. decreases expression of the VKORC1 gene.d. increases expression of the VKORC1 gene.
The correct answer - c. decreases expression of the VKORC1 gene.
Explanation:
Mutation of Guanine nucleotide into Adenosine is the reason for this particular type of mutation. This mutation expresses the less expression of the VKORC1 protein.
The mutation results in a decrease in the affinity of the binding site of the transcription factor which causes less expression. Since the VKORC1 protein is less in the body so Warfarin doses are decreased
Thus, the correct answer is - decreases expression of the VKORC1 gene.
Dimples is the dominant trait (D). Your friend has dimples so that means he or she should have at least one allele of the dominant trait to express that trait. So your friend would either be homozygous dominant (DD) or heterozygous dominant (Dd). Notice that there is a recessive allele in the second. Even with that present, dimples would be still expressed.
Fossil fuels are fuels which are formed over millions of years from dead remains of plants and animals buried under rocks. Heat from inside the earth and pressure from rock changes the dead remains into oil, natural gas and coal. Because these fuels cannot be replenish again they are called as nonrenewable fuels.
