None because they are children play toys not scientific tools!
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Steroids
are complex structure four connected rings of carbon atoms. They are cholesterol which is in all body cells and used to synthesize other steroids:sex hormones, such as estrogen, and testosterone and several hormones from the adrenal glands.
Waxes
are comprised of an ester of a long-chain alcohol and a fatty acid. Many plants have leaves and fruits with wax coatings to help prevent water loss.
Phospholipids
consist of Glycerol portion and fatty acid chains. Only two fatty acids chains; in place of the third is portion that include a phosphate group. THe phosphate portion is soluble in water [hydrophobic] forms the ''head'' of the molecule, while the fatty acids portion is insoluble in water [hydrophobic] and forms a ''tail''.
Fats
to store energy for cellular activities. Carbohydrates fat molecules are composed of carbon, hydrogen and oxygen atoms.
Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
