Answer:
There are not too many disadvantages of endoskeleton . 
This is why most large animal around have them. 
one large animal has one of the vunerability animals face without exoskeleton. 
Explanation:
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The mountains in Buffalo because of the temperature.
        
             
        
        
        
The rotation of the Earth in its axis
        
             
        
        
        
I think the answer is Phenylketonuria.