Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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Answer:
the forces between the two charges is directly proportional to the product of the charges and inversely proportional to the square of the distance between them
B. producer because most autotrophs are green plants use light for energy.
Answer:
Carbon dioxide and oxygen are recycled through photosynthesis and cellular
respiration forever unless something interrupts.
Explanation:
Photosynthesis and cellular respiration are two distinct and opposite metabolical processes undergone by living cells. They are opposite processes because one utilizes the products of the other as reactants.
Photosynthesis is a unique process to autotrophic organisms like plants. It is the process whereby plants synthesize their food in form of organic molecules (glucose) by combining Carbondioxide (CO2) and water (H2O) in the presence of sunlight.
The overall equation of photosynthesis is as follows:
6CO2 + 6H2O ------> C6H12O6+ 6O2
On the other hand, cellular respiration is the process whereby living cells obtain energy (ATP) by breaking down food molecules (glucose) using oxygen to produce carbondioxide (CO2) and water as products. The overall equation is:
C6H12O6 + 602 -----> 6CO2 + 6H2O
Based on the lab experiments, it can be concluded that Carbon dioxide and oxygen are recycled through photosynthesis and cellular
respiration because photosynthesis recycles/reuses the products of cellular respiration, which are C02 and H2O while cellular respiration recycles/reuses the products of photosynthesis, which are C6H12O6 and O2. This process occurs naturally in the environment and will continue to do so unless something interupts.
Option B is incorrect because light energy from the sun powers photosynthesis while option C is incorrect because photosynthesis transforms light energy to chemical energy while cellular respiration transforms chemical energy to thermal energy.
