By haphazardly introducing a transgene harboring a disease-causing mutant variant of the HTT gene into the genome of a mouse or primate, it is possible to produce an animal model with the majority of the symptoms of this condition. Here option B is the correct answer.
Huntington's disease is an uncommon, genetic condition that results in the gradual degeneration of brain nerve cells. Huntington's illness, which frequently results in mobility, cognitive, and psychological problems, has a substantial impact on a person's functional capacities.
A DNA region known as a CAG trinucleotide repeat is involved in the HTT mutation that causes Huntington's disease. Three DNA-building building pieces that are repeated several times in a row make up this region.
Complete question:
Huntington's disease is a dominant disease caused by the expansion of the trinucleotide repeat region of the Htt gene that results in the production of a Huntingtin protein with an expanded number of glutamines. An animal model with most features of this syndrome could be created by
A - knocking in a wild-type copy of the Htt gene to a mouse or primate genome.
B - randomly inserting a transgene containing a wild-type allele of the Htt gene to a mouse or primate genome.
C - randomly inserting a transgene containing a disease-causing mutant allele of the Htt gene into a mouse or primate genome
D - knocking out one copy of the wild-type Htt gene from a mouse or primate genome.
E - knocking out both copies of the wild-type Htt gene from a mouse or primate genome.
To learn more about Huntington's disease
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