The main difference in the human and mouse skin is the number of layers i e. human skin have 6 to 10 layers of epidermis while mouse has only 3 layers. Worm has 302 neurons in its nervous system as compared to the 86 billion neurons present in human body because of difference in size. the main difference in human and fly muscles is that fly has strong muscle responsible for flight in the air while human has no flight muscles. The main difference of human and frog blood is the red blood cells. human has RBC with no nucleus while frog has red blood cells having nucleus.