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elixir [45]
3 years ago
6

Question 11 of 20 What fact do scientists believe provides evidence for the Big Bang Theory? A. All stars feature nuclear fusion

in their core. B. Most extra-solar planets are gas giants C. All comets follow elliptical orbits. D. All distant galaxies are moving away from us.
​
Biology
1 answer:
natka813 [3]3 years ago
5 0
The smart answer is A because it makes more sense
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What role can exosomes play in disease treatment? who can tell me detailed information? Any help would be appreciated. Thanks in
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Exosomes as Therapeutic Target

Given the fact that elevated exosome levels are often correlated with greater severity of different types of cancer, reducing circulating exosomes to normal levels is one of therapeutic strategies to increase treatment efficacy. There are different approaches to modulate exosome production: 1) Inhibition of exosome formation: inhibit crucial proteins involved in exosome formation pathway; 2) Inhibition of exosome release: inhibit important regulators of exosome release process, increased intracellular Ca2+, change cellular microenvironmental pH; 3) Inhibition of exosome uptake: add proteinase for surface proteins on exosomes may serve as receptors for uptake pathways. In addition to control exosomes production, removal of exosomes from the entire circulatory system might be a novel strategy for cancer treatment.

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Exosomes as Targeted Drug Delivery Vehicles

Exosomes became one of the most common methods applied in drug delivery system because of several advantages they have. Firstly, exosomes normally have a small size 40-100 nm, which is more homogenous compared to other microvesicles. This will lead them to evade rapid clearance by the mononuclear phagocyte and enhances passage through fenestrations in the vessel wall. Secondly, due to their endogenous origin, they are less toxic for and better tolerated by the immune system. It facilitates them to avoid causing side effects that normally occur with synthetic nanoparticles. Additionally, the specific ligand or protein expressed on the exosome surface increases efficiency of cargo into the cytosol of the target cell, and therefore fewer off-target effects. Exosomes are generally found most useful as a drug delivery medium in cancer therapy, anti-inflammation and gene interference therapy such as transferring of miRNA.

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Explanation:

https://www.creative-biostructure.com/exosome-applications-652.htm

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